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Severity of intervertebral disc herniation regulates cytokine and chemokine levels in patients with chronic radicular back pain
- Source :
- Osteoarthritis Cartilage
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Summary Objective The contributions of intervertebral disc disease and subject-specific covariates to systemic inflammation in low back pain are unknown. We examined the effects of symptomatic disc herniation (DH) and MRI herniation severity on serum cytokine levels in clinical subjects. Design Cytokine levels from lumbar DH subjects (N = 78) were compared to control subjects (N = 57) accounting for effects of DH, age, body mass index (BMI) and gender. Effect of DH severity on cytokine levels was analyzed on subsets of subjects with acute or chronic pain. Serum cytokines were also analyzed in a subset of patients between pre- and 3 months post-surgery. Results Cytokine levels were elevated in the serum of patients with symptomatic DH, and the covariates age, BMI and gender significantly contributed to levels of some cytokines. Severity of herniation was a significant contributor to pain intensity (VAS), serum levels of HMGB1, PDGFbb, and IL-9. The relationship between DH severity and cytokine levels was confirmed in subjects with chronic, but not acute symptoms. Serum levels of macrophage migration inhibitory factor (MIF) decreased, whereas levels of CCL3, CCL11, CXCL1, and CXCL10 were significantly elevated post surgery. Conclusions This study is the first to show that DH severity is coordinately associated with changes in serum levels of inflammatory cytokines in chronic pain subjects. HMGB1, PDGFbb and IL-9 are novel mediators of increasing DH severity, indicative of cellular damage, neuro-inflammation and angiogenesis. Resolution of inflammation was observed with decrease in MIF post surgery. However, elevated chemokine levels indicate ongoing remodeling and wound healing at 3-month time point.
- Subjects :
- Male
0301 basic medicine
Chemokine CXCL1
medicine.medical_treatment
Becaplermin
Systemic inflammation
Severity of Illness Index
Gastroenterology
Body Mass Index
0302 clinical medicine
Back pain
Medicine
Orthopedics and Sports Medicine
HMGB1 Protein
Radiculopathy
Chemokine CCL3
Pain Measurement
Lumbar Vertebrae
Age Factors
Chronic pain
Middle Aged
Acute Pain
Magnetic Resonance Imaging
Low back pain
CXCL1
Cytokine
Cytokines
Female
Chemokines
Chronic Pain
medicine.symptom
Intervertebral Disc Displacement
Adult
Chemokine CCL11
medicine.medical_specialty
Biomedical Engineering
Article
Proinflammatory cytokine
03 medical and health sciences
Sex Factors
Rheumatology
Internal medicine
Humans
CXCL10
Macrophage Migration-Inhibitory Factors
030203 arthritis & rheumatology
business.industry
Interleukin-9
medicine.disease
Chemokine CXCL10
030104 developmental biology
business
Low Back Pain
Subjects
Details
- ISSN :
- 10634584
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Osteoarthritis and Cartilage
- Accession number :
- edsair.doi.dedup.....887d11f561cf8a3ba4f98fa23ac726da