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Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study

Authors :
Marek Brabec
Marisa A. Nunes
Juraj Michalec
Jana Urbanová
Arian Taniwall
Matthew Campbell
Jan Brož
Ludmila Brunerová
Vojtěch Berka
Jan Polak
Denisa Janíčková Žďárská
Dario Rahelić
Source :
Nutrients, Nutrients; Volume 13; Issue 11; Pages: 4165, Nutrients, Vol 13, Iss 4165, p 4165 (2021)
Publication Year :
2021
Publisher :
MDPI, 2021.

Abstract

The glycemic response to ingested glucose for the treatment of hypoglycemia following exercise in type 1 diabetes patients has never been studied. Therefore, we aimed to characterize glucose dynamics during a standardized bout of hypoglycemia-inducing exercise and the subsequent hypoglycemia treatment with the oral ingestion of glucose. Ten male patients with type 1 diabetes performed a standardized bout of cycling exercise using an electrically braked ergometer at a target heart rate (THR) of 50% of the individual heart rate reserve, determined using the Karvonen equation. Exercise was terminated when hypoglycemia was reached, followed by immediate hypoglycemia treatment with the oral ingestion of 20 g of glucose. Arterialized blood glucose (ABG) levels were monitored at 5 min intervals during exercise and for 60 min during recovery. During exercise, ABG decreased at a mean rate of 0.11 ± 0.03 mmol/L·min−1 (minimum: 0.07, maximum: 0.17 mmol/L·min−1). During recovery, ABG increased at a mean rate of 0.13 ± 0.05 mmol/L·min−1 (minimum: 0.06, maximum: 0.19 mmol/L·min−1). Moreover, 20 g of glucose maintained recovery from hypoglycemia throughout the 60 min postexercise observation window.

Details

Language :
English
ISSN :
20726643
Volume :
13
Issue :
11
Database :
OpenAIRE
Journal :
Nutrients
Accession number :
edsair.doi.dedup.....88909f2618cfd27cfc3f0c751fd7766b