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Characterization of Individualized Glycemic Excursions during a Standardized Bout of Hypoglycemia-Inducing Exercise and Subsequent Hypoglycemia Treatment—A Pilot Study
- Source :
- Nutrients, Nutrients; Volume 13; Issue 11; Pages: 4165, Nutrients, Vol 13, Iss 4165, p 4165 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- The glycemic response to ingested glucose for the treatment of hypoglycemia following exercise in type 1 diabetes patients has never been studied. Therefore, we aimed to characterize glucose dynamics during a standardized bout of hypoglycemia-inducing exercise and the subsequent hypoglycemia treatment with the oral ingestion of glucose. Ten male patients with type 1 diabetes performed a standardized bout of cycling exercise using an electrically braked ergometer at a target heart rate (THR) of 50% of the individual heart rate reserve, determined using the Karvonen equation. Exercise was terminated when hypoglycemia was reached, followed by immediate hypoglycemia treatment with the oral ingestion of 20 g of glucose. Arterialized blood glucose (ABG) levels were monitored at 5 min intervals during exercise and for 60 min during recovery. During exercise, ABG decreased at a mean rate of 0.11 ± 0.03 mmol/L·min−1 (minimum: 0.07, maximum: 0.17 mmol/L·min−1). During recovery, ABG increased at a mean rate of 0.13 ± 0.05 mmol/L·min−1 (minimum: 0.06, maximum: 0.19 mmol/L·min−1). Moreover, 20 g of glucose maintained recovery from hypoglycemia throughout the 60 min postexercise observation window.
- Subjects :
- Adult
Blood Glucose
Male
type 1 diabetes
Administration, Oral
Pilot Projects
Hypoglycemia
Target heart rate
Article
Heart Rate
medicine
Humans
Insulin
TX341-641
Glucose dynamics
glycemic excursion
Glycemic
Type 1 diabetes
hypoglycemia treatment
Nutrition and Dietetics
exercise
business.industry
Nutrition. Foods and food supply
medicine.disease
hypoglycemia
insulin therapy
Bicycling
Oral ingestion
Diabetes Mellitus, Type 1
Glucose
Male patient
Anesthesia
Heart rate reserve
business
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 13
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....88909f2618cfd27cfc3f0c751fd7766b