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Integration of chemoreceptor stimuli by caudal pontile and rostral medullary sites
- Source :
- Journal of Applied Physiology. 41:612-622
- Publication Year :
- 1976
- Publisher :
- American Physiological Society, 1976.
-
Abstract
- Ventilatory regulation by pontile pneumotaxic and apneustic centers and by rostral medullary sites was evaluated in intercollicular decerebrate cats. Following pneumotaxic center ablation, PAco2 was significantly elevated.Moreover, in response to hypercapina or hypoxia, frequency responses were significantly diminished whereas tidal volume responses were unchanged or elevated. Interruption of apneustic center function by caudal pontile transection or radiofrequency lesions in the caudal pons and/or rostral medulla resulted in significant decreases of tidal volume responses and significant elevations of frequency responses to both hypercapnia and hypoxia. Neither minute volume responses nor the PAco2 level was altered. It is concluded that the apneustic center exercises a primary role in the brainstem definitionof tidal volume responses for both peripheral and central chemoreceptor afferent stimuli. The apneustic center is also considered to exert an impoetant function in the definition of respiratory frequency. A medially placed pathway in the rostral medulla is proposed to interconnect the apneustic center with the medullary respiratory nuclei.
- Subjects :
- Male
Chemoreceptor
Medullary cavity
Apnea
Physiology
Partial Pressure
Pneumotaxic center
Hypercapnia
Stereotaxic Techniques
Pons
Physiology (medical)
Tidal Volume
Animals
Medicine
Hypoxia
Medulla Oblongata
business.industry
Reticular Formation
Anatomy
Carbon Dioxide
Decerebrate cats
Chemoreceptor Cells
Oxygen
medicine.anatomical_structure
Cats
Female
business
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 15221601 and 87507587
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Journal of Applied Physiology
- Accession number :
- edsair.doi.dedup.....8896186918c58458ed4da4c801b42275