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Clinical effects of cervical conization with positive margins in cervical cancer
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Radical surgery after cervical conization is a common approach for the treatment of cervical cancer. In some cases, disease progression is observed after positive margins at conization, but the effect of conization on disease progression remains unclear. Thus, the aim of this study was to investigate the clinical outcomes of positive margins at conization in cervical cancer. A total of 101 patients who underwent cervical conization before radical hysterectomy and pelvic lymph node dissection were considered eligible by reviewing medical records. The association between the positive margins and patient outcomes, including subsequent lymph node metastasis, was evaluated. The rate of lymphovascular space invasion (LVSI) positivity at radical surgery was significantly higher in patients with positive margins (p = 0.017) than in those with negative margins, although there was no significant difference in the rate of pelvic lymph node metastasis (p = 0.155). Moreover, there was no significant difference in the overall survival or progression-free survival between the two groups (p = 0.332 and 0.200, respectively). A positive margin at conization presented no significant prognostic disadvantage; thus, diagnostic conization is one of the most suitable treatment options for early-stage cervical cancer that is difficult to accurately assess.
- Subjects :
- Adult
medicine.medical_specialty
medicine.medical_treatment
Science
Conization
Uterine Cervical Neoplasms
Cervix Uteri
Hysterectomy
Article
Pelvis
Young Adult
Medicine
Humans
Radical Hysterectomy
Radical surgery
Lymph node
Aged
Neoplasm Staging
Cancer
Cervical cancer
Multidisciplinary
business.industry
Medical record
Margins of Excision
Middle Aged
medicine.disease
Cervical conization
Prognosis
Lymphovascular
Survival Rate
Dissection
medicine.anatomical_structure
Treatment Outcome
Oncology
Lymphatic Metastasis
Disease Progression
Lymph Node Excision
Female
Radiology
Lymph Nodes
business
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....889bae78c56e8dcc26d560c402656c6d