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Wireless, Skin‐Interfaced Devices for Pediatric Critical Care: Application to Continuous, Noninvasive Blood Pressure Monitoring

Authors :
Avani Shukla
John A. Rogers
Jamie L. Vogl
Michael Johnson
Raudel Avila
Yonggang Huang
Jean Won Kwak
Shuai Xu
Shupeng Li
Jairo Chavez
Joohee Kim
Ha Uk Chung
Lauren E. Marsillio
Casey M. Rand
Kelsey B. Fields
Dennis Ryu
Aurélie Hourlier-Fargette
Sue J. Hong
Allison Bradley
Han Heul Jo
Surabhi R. Madhvapathy
Emma C. Dunne
Andreas Tzavelis
Jun Bin Park
Masahiro Irie
Debra E. Weese-Mayer
Jungwoo Kim
Jong Yoon Lee
Jin-Tae Kim
Sung Soo Kwak
Seung Sik Kim
Claire Liu
Donghyun Kim
Joanna L. Ciatti
Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA
Northwestern University [Evanston]
School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea
Institut Charles Sadron (ICS)
Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique
Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE)
Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Division of Pediatric Autonomic Medicine, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA
Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA
Sibel Health, Niles, IL, 60714, USA
Division of Critical Care, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA
Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA
Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Division of Neurology, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA
Department of Neurological Surgery Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Source :
Advanced Healthcare Materials, Advanced Healthcare Materials, Wiley, 2021, 10 (17), pp.2100383. ⟨10.1002/adhm.202100383⟩
Publication Year :
2021
Publisher :
Wiley, 2021.

Abstract

International audience; Indwelling arterial lines, the clinical gold standard for continuous blood pressure (BP) monitoring in the pediatric intensive care unit (PICU), have significant drawbacks due to their invasive nature, ischemic risk, and impediment to natural body movement. A noninvasive, wireless, and accurate alternative would greatly improve the quality of patient care. Recently introduced classes of wireless, skin-interfaced devices offer capabilities in continuous, precise monitoring of physiologic waveforms and vital signs in pediatric and neonatal patients, but have not yet been employed for continuous tracking of systolic and diastolic BP—critical for guiding clinical decision-making in the PICU. The results presented here focus on materials and mechanics that optimize the system-level properties of these devices to enhance their reliable use in this context, achieving full compatibility with the range of body sizes, skin types, and sterilization schemes typically encountered in the PICU. Systematic analysis of the data from these devices on 23 pediatric patients, yields derived, noninvasive BP values that can be quantitatively validated against direct recordings from arterial lines. The results from this diverse cohort, including those under pharmacological protocols, suggest that wireless, skin-interfaced devices can, in certain circumstances of practical utility, accurately and continuously monitor BP in the PICU patient population.

Details

ISSN :
21922659 and 21922640
Volume :
10
Database :
OpenAIRE
Journal :
Advanced Healthcare Materials
Accession number :
edsair.doi.dedup.....88a45ecfa99fcc91e489c46efdcfc3c9
Full Text :
https://doi.org/10.1002/adhm.202100383