Back to Search
Start Over
Accelerated pubertal onset in short children with delayed bone age
- Source :
- Journal of Pediatric Endocrinology and Metabolism. 35:163-168
- Publication Year :
- 2021
- Publisher :
- Walter de Gruyter GmbH, 2021.
-
Abstract
- Objectives Constitutional delay of growth (CDG) is usually associated with a delay in pubertal onset (CDGP) and a catch-up growth after puberty. Some individuals, however, have earlier-than-expected pubertal onset resulting in a shorter adult height. We investigated the current incidence of such individuals and that of 30 years ago. Methods The study subjects are 1,312 consecutive Japanese children referred to Osaka City General Hospital (OCGH) for short stature during 2010–2018, and a cohort of 11,256 individuals in the Ogi Growth Research (OGR, 1979–1992). Individuals with the height standard deviation score Results From the OCGH cohort, 55 children (38 boys, 17 girls) met the criteria, and earlier-than-expected onset was observed in 34.2% of boys and 29.4% of girls. In the 73 short individuals with delayed bone age in the OGR cohort, earlier-than-expected onset was less common (13.0% for boys and 14.8% for girls). There was no significant association between the timing of pubertal growth onset and the BA/CA ratio, IGF-1, and midparental height. Conclusions Earlier-than-expected pubertal growth onset is common in CDG and possibly increasing.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Adolescent
Endocrinology, Diabetes and Metabolism
Population
Short stature
Endocrinology
Age Determination by Skeleton
medicine
Humans
General hospital
Child
education
Puberty, Delayed
education.field_of_study
business.industry
Incidence (epidemiology)
Age Factors
Bone age
Growth curve (biology)
Body Height
Pediatrics, Perinatology and Child Health
Cohort
Female
medicine.symptom
business
Puberty onset
Subjects
Details
- ISSN :
- 21910251 and 0334018X
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Journal of Pediatric Endocrinology and Metabolism
- Accession number :
- edsair.doi.dedup.....88c5c6a99cd1487daebce51be113db89