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STK39, But Not BST1, HLA-DQB1, and SPPL2B Polymorphism, Is Associated With Han-Chinese Parkinson's Disease in Taiwan
- Source :
- Medicine
- Publication Year :
- 2015
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2015.
-
Abstract
- Neuroinflammation is emerging as an important pathway involved in Parkinson's disease (PD) pathogenesis. Herein, we investigated the effect of 4 top PD-associated genetic variants in Caucasians listed on the top risk loci identified by meta-analysis of genome wide-association studies in PDGene database (http://www.pdgene.org/top_results), including serine threonine kinase 39 (STK39) rs1955337, bone marrow stromal cell antigen 1 (BST1) rs11724635, major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1) rs9275326, and signal peptide peptidase-like 2B (SPPL2B) rs62120679, by genotyping 596 Han-Chinese patients with PD and 597 age-matched control subjects. Compared with subjects with STK39 rs1955337 GG genotype, those with TT genotype had a 1.64-fold increased risk of PD (95% confidence interval: 1.13–2.39, P = 0.010). The recessive model also demonstrated an increased PD risk in TT genotype (odds ratio: 1.59, 95% confidence interval: 1.12–2.27) compared with the other genotypes (GT + GG). PD patients demonstrate a similar genotypic and allelic frequency in BST1 rs11724635, HLA-DQB1 rs9275326, and SPPL2B rs62120679 compared with controls. These findings suggested that the STK39 rs1955337 TT genotype is a risk factor for Han-Chinese patients with PD in Taiwan. The ethnic discrepancies of the other 3 genetic variants may indicate a distinct genetic background of neuroinflammation between PD patients in Han-Chinese and Caucasians.
- Subjects :
- Adult
Genotype
Taiwan
Observational Study
Protein Serine-Threonine Kinases
GPI-Linked Proteins
Major histocompatibility complex
Young Adult
Asian People
Gene Frequency
Antigens, CD
Polymorphism (computer science)
Ethnicity
Aspartic Acid Endopeptidases
HLA-DQ beta-Chains
Humans
Medicine
Genetic Predisposition to Disease
Risk factor
ADP-ribosyl Cyclase
Genotyping
Allele frequency
Aged
Aged, 80 and over
HLA-DQB1
biology
business.industry
Parkinson Disease
General Medicine
Odds ratio
Middle Aged
Immunology
biology.protein
business
Research Article
Subjects
Details
- ISSN :
- 00257974
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....88c75e20e9df9ff31d7872b75ae078b3