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Relationship between disease activity, organ damage and health-related quality of life in patients with systemic lupus erythematosus: A systemic review and meta-analysis
- Source :
- Autoimmunity reviews. 20(1)
- Publication Year :
- 2020
-
Abstract
- Objectives Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease that may lead to considerable physical, psychological, and socioeconomical burden. In previous studies, inconsistent results were reported for the association of disease activity and organ damage with health-related quality of life (HRQoL). This paper aimed to explore the relationship between disease activity, organ damage, and HRQoL measured by SF-36, EQ-5D, LupusQoL, and LupusPRO and investigate whether the correlation is region-specific. Methods We systematically searched for studies reporting the association between SLE disease activity, organ damage, and HRQoL in MEDLINE, EMBASE, PsycINFO, World of Science, the Cochrane Library, and CINAHL from inception to December 2019. A meta-analysis and region subgroup analysis were performed with a random-effects model to estimate pooled correlation coefficients and heterogeneity. Results Forty articles were included representing of 6079 adult SLE patients. The meta-analysis of SF-36 and LupusPRO studies revealed mild to moderate negative correlations between disease activity and domains of these HRQoL measurements (correlation coefficient r ranging from −0.27 to −0.07). Likewise, negative correlations were found between organ damage and domains of SF-36 and LupusPRO (r ranging from −0.25 to −0.08). The pooled correlation coefficient is relatively higher in physical functioning related domains than mental health. In the region subgroup analysis, disease activity had strong negative correlations with SF-36 domains in African and European SLE patients, while organ damage had the strongest negative correlation with SF-36 domains in Asian SLE patients (p Conclusion This study provides the first comprehensive assessment of the relationship between disease activity, organ damage, and four popular HRQoL instruments, which provides useful insight into the target therapy in SLE management.
- Subjects :
- 0301 basic medicine
Adult
medicine.medical_specialty
Health Status
Immunology
MEDLINE
Subgroup analysis
PsycINFO
CINAHL
Cochrane Library
Severity of Illness Index
03 medical and health sciences
0302 clinical medicine
Quality of life
Internal medicine
Surveys and Questionnaires
Immunology and Allergy
Medicine
Humans
Lupus Erythematosus, Systemic
030203 arthritis & rheumatology
business.industry
Mental health
030104 developmental biology
Meta-analysis
Quality of Life
business
Subjects
Details
- ISSN :
- 18730183
- Volume :
- 20
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Autoimmunity reviews
- Accession number :
- edsair.doi.dedup.....8907aabf8009eb286e0af0c42ba14082