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Noggin acts downstream of Wnt and Sonic Hedgehog to antagonize BMP4 in avian somite patterning
- Source :
- HAL, ResearcherID, Europe PubMed Central, Development (Cambridge, England), Development (Cambridge, England), 1997, Development (Cambridge, England), Company of Biologists, 1997
- Publication Year :
- 1997
- Publisher :
- The Company of Biologists, 1997.
-
Abstract
- In the vertebrate embryo, the lateral compartment of the somite gives rise to muscles of the limb and body wall and is patterned in response to lateral-plate-derived BMP4. Activation of the myogenic program distinctive to the medial somite, i.e. relatively immediate development of the epaxial muscle lineage, requires neutralization of this lateral signal. We have analyzed the properties of molecules likely to play a role in opposing lateral somite specification by BMP4. We propose that the BMP4 antagonist Noggin plays an important role in promoting medial somite patterning in vivo. We demonstrate that Noggin expression in the somite is under the control of a neural-tube-derived factor, whose effect can be mimicked experimentally by Wnt1. Wnt1 is appropriately expressed in the neural tube. Furthermore, we show that Sonic Hedgehog is able to activate ectopic expression of Noggin resulting in the blocking of BMP4 specification of the lateral somite. Our results are consistent with a model in which Noggin activation lies downstream of the SHH and Wnt signaling pathways.
- Subjects :
- muscle lineages
Xenopus
Bone Morphogenetic Protein 4
Chick Embryo
Xenopus Proteins
paraxial mesoderm
0302 clinical medicine
Cricetinae
[SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]
Sonic hedgehog
In Situ Hybridization
ComputingMilieux_MISCELLANEOUS
neural tube
0303 health sciences
biology
Muscles
Wnt signaling pathway
Gene Expression Regulation, Developmental
Cell biology
chick
Sonic Hedgehog
medicine.anatomical_structure
Somites
Bone morphogenetic protein 4
Bone Morphogenetic Proteins
embryonic structures
Signal Transduction
medicine.medical_specialty
animal structures
Dermomyotome
CHO Cells
Wnt1 Protein
Models, Biological
Wnt
03 medical and health sciences
Noggin
Proto-Oncogene Proteins
Internal medicine
lateral plate
medicine
Animals
Compartment (development)
Hedgehog Proteins
Molecular Biology
030304 developmental biology
Somite specification
Proteins
[SDV.BDD.MOR]Life Sciences [q-bio]/Development Biology/Morphogenesis
somite patterning
Zebrafish Proteins
Wnt Proteins
Somite
[SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis
Endocrinology
Trans-Activators
biology.protein
Carrier Proteins
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- ISSN :
- 14779129 and 09501991
- Volume :
- 124
- Database :
- OpenAIRE
- Journal :
- Development
- Accession number :
- edsair.doi.dedup.....8917c9c4f063cdb4b0dd61bd7dece93e