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The emerging role of KDM5A in human cancer
- Source :
- Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-18 (2021), Journal of Hematology & Oncology
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Histone methylation is a key posttranslational modification of chromatin, and its dysregulation affects a wide array of nuclear activities including the maintenance of genome integrity, transcriptional regulation, and epigenetic inheritance. Variations in the pattern of histone methylation influence both physiological and pathological events. Lysine-specific demethylase 5A (KDM5A, also known as JARID1A or RBP2) is a KDM5 Jumonji histone demethylase subfamily member that erases di- and tri-methyl groups from lysine 4 of histone H3. Emerging studies indicate that KDM5A is responsible for driving multiple human diseases, particularly cancers. In this review, we summarize the roles of KDM5A in human cancers, survey the field of KDM5A inhibitors including their anticancer activity and modes of action, and the current challenges and potential opportunities of this field.
- Subjects :
- 0301 basic medicine
Cancer Research
Antineoplastic Agents
Review
lcsh:RC254-282
Jumonji C domain
Histone methylation
Histones
Targeted therapy
03 medical and health sciences
Histone H3
0302 clinical medicine
Neoplasms
Drug Discovery
Transcriptional regulation
Animals
Humans
Molecular Targeted Therapy
Epigenetics
Molecular Biology
Cancer
biology
lcsh:RC633-647.5
lcsh:Diseases of the blood and blood-forming organs
Hematology
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Chromatin
Cell biology
030104 developmental biology
Histone
Oncology
Drug resistance
030220 oncology & carcinogenesis
KDM5A
biology.protein
Demethylase
Retinoblastoma-Binding Protein 2
Subjects
Details
- ISSN :
- 17568722
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of Hematology & Oncology
- Accession number :
- edsair.doi.dedup.....89242ac1aa487820f59d05ae0d9b8a8e