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Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia
- Source :
- European Archives of Psychiatry and Clinical Neuroscience. 266:495-504
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Profound white matter abnormalities have repeatedly been described in schizophrenia, which involve the altered expression of numerous oligodendrocyte-associated genes. Transcripts of the disrupted-in-schizophrenia 1 (DISC1) gene, a key susceptibility factor in schizophrenia, have recently been shown to be expressed by oligodendroglial cells and to negatively regulate oligodendrocyte differentiation and maturation. To learn more about the putative role(s) of oligodendroglia-associated DISC1 in schizophrenia, we analyzed the density of DISC1-immunoreactive oligodendrocytes in the fronto-parietal white matter in postmortem brains of patients with schizophrenia. Compared with controls (N = 12) and cases with undifferentiated/residual schizophrenia (N = 6), there was a significantly increased density of DISC1-expressing glial cells in paranoid schizophrenia (N = 12), which unlikely resulted from neuroleptic treatment. Pathophysiologically, over-expression of DISC1 protein(s) in white matter oligodendrocytes might add to the reduced levels of two myelin markers, 2',3'-cyclic-nucleotide 3'-phosphodiesterase and myelin basic protein in schizophrenia. Moreover, it might significantly contribute to cell cycle abnormalities as well as to deficits in oligodendroglial cell differentiation and maturation found in schizophrenia.
- Subjects :
- Adult
Male
medicine.medical_specialty
Paranoid schizophrenia
Nerve Tissue Proteins
behavioral disciplines and activities
Statistics, Nonparametric
White matter
03 medical and health sciences
DISC1
Myelin
0302 clinical medicine
Parietal Lobe
Internal medicine
mental disorders
medicine
Humans
Pharmacology (medical)
Biological Psychiatry
Aged
Schizophrenia, Paranoid
biology
Oligodendrocyte differentiation
Myelin Basic Protein
General Medicine
Middle Aged
medicine.disease
White Matter
Frontal Lobe
030227 psychiatry
Myelin basic protein
Oligodendroglia
Psychiatry and Mental health
Endocrinology
medicine.anatomical_structure
Gene Expression Regulation
Frontal lobe
Schizophrenia
biology.protein
Female
2',3'-Cyclic-Nucleotide Phosphodiesterases
Psychology
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14338491 and 09401334
- Volume :
- 266
- Database :
- OpenAIRE
- Journal :
- European Archives of Psychiatry and Clinical Neuroscience
- Accession number :
- edsair.doi.dedup.....8928c18aff868b110ed0849da3a3f771