Back to Search
Start Over
Evidence for linkage between K88ab, K88ac intestinal receptors to Escherichia coli and transferrin loci in pigs
- Source :
- Animal Genetics, Animal Genetics, Wiley-Blackwell, 1993, 24, pp.393-396
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- Segregation at the loci coding for the K88ab and K88ac small intestinal receptors to E. coli adhesins (K88abR, K88acR) and at the transferrin (TF) locus was studied in 38 pig families including 273 piglets. The TF locus showed a segregation deviation towards the B variant while each of the K88 receptors behaved as a single autosomal dominant gene. Recombinants between K88abR and K88acR provide evidence that they are under the control of two different loci. Thirty-two triple backcross families were selected to test linkage and estimate recombination rates (theta). Our results demonstrate that the two K88 receptor loci are closely linked (theta = 0.02) with a maximum lod score value (Zm) of 46.0. In addition, they are linked to the TF locus, theta = 0.14, Zm = 19.6 for the K88abR locus and theta = 0.16, Zm = 17.9 for the K88acR locus. The estimated recombination rates, smaller in males than in females, are consistent with the order TF-K88abR-K88acR. This linkage thus localizes the K88 loci, as the TF locus, on chromosome 13.
- Subjects :
- Male
Genetic Linkage
Swine
Locus (genetics)
[SDV.GEN] Life Sciences [q-bio]/Genetics
Biology
medicine.disease_cause
Bacterial Adhesion
03 medical and health sciences
Gene mapping
Genetic linkage
Intestine, Small
Escherichia coli
Genetics
medicine
Animals
Receptors, Immunologic
Receptor
Gene
030304 developmental biology
Chromosome 13
Recombination, Genetic
chemistry.chemical_classification
Adhesins, Escherichia coli
Antigens, Bacterial
[SDV.GEN]Life Sciences [q-bio]/Genetics
0303 health sciences
Chi-Square Distribution
Escherichia coli Proteins
Transferrin
0402 animal and dairy science
04 agricultural and veterinary sciences
General Medicine
040201 dairy & animal science
Molecular biology
Pedigree
chemistry
Antigens, Surface
Electrophoresis, Polyacrylamide Gel
Female
Animal Science and Zoology
Fimbriae Proteins
Lod Score
Bacterial Outer Membrane Proteins
Subjects
Details
- ISSN :
- 13652052 and 02689146
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Animal Genetics
- Accession number :
- edsair.doi.dedup.....892b617f6d53ca790e1f0abbf878f6c4