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Evolutionary Relationships of Ljungan Virus Variants Circulating in Multi-Host Systems across Europe
- Source :
- Viruses, Volume 13, Issue 7, Viruses, Vol 13, Iss 1317, p 1317 (2021)
- Publication Year :
- 2021
-
Abstract
- The picornavirus named ‘Ljungan virus’ (LV, species Parechovirus B) has been detected in a dozen small mammal species from across Europe, but detailed information on its genetic diversity and host specificity is lacking. Here, we analyze the evolutionary relationships of LV variants circulating in free-living mammal populations by comparing the phylogenetics of the VP1 region (encoding the capsid protein and associated with LV serotype) and the 3Dpol region (encoding the RNA polymerase) from 24 LV RNA-positive animals and a fragment of the 5′ untranslated region (UTR) sequence (used for defining strains) in sympatric small mammals. We define three new VP1 genotypes: two in bank voles (Myodes glareolus) (genotype 8 from Finland, Sweden, France, and Italy, and genotype 9 from France and Italy) and one in field voles (Microtus arvalis) (genotype 7 from Finland). There are several other indications that LV variants are host-specific, at least in parts of their range. Our results suggest that LV evolution is rapid, ongoing and affected by genetic drift, purifying selection, spillover and host evolutionary history. Although recent studies suggest that LV does not have zoonotic potential, its widespread geographical and host distribution in natural populations of well-characterized small mammals could make it useful as a model for studying RNA virus evolution and transmission.
- Subjects :
- 0301 basic medicine
VOLES MYODES-GLAREOLUS
Picornavirus
MITOCHONDRIAL-DNA
Parechovirus
Picornaviridae
Zoonosis
Settore BIO/05 - ZOOLOGIA
Genotype
Small mammals
MOLECULAR CHARACTERIZATION
MAXIMUM-LIKELIHOOD
Phylogeny
11832 Microbiology and virology
Mammals
biology
Bank vole
LYMPHOCYTIC CHORIOMENINGITIS
CLINICAL-SAMPLES
QR1-502
Europe
Infectious Diseases
Ljungan virus
Rodent-borne virus
PUBLIC-HEALTH
SEROLOGICAL SURVEY
030106 microbiology
Microbiology
Article
Host Specificity
Evolution, Molecular
03 medical and health sciences
Genetic drift
Phylogenetics
Virology
Animals
Ljungan virus isolates
Microtus
HUMAN PARECHOVIRUSES
Genetic diversity
Evolutionary Biology
Picornaviridae Infections
Genetic Variation
biology.organism_classification
030104 developmental biology
Evolutionary biology
PUUMALA VIRUSES
3111 Biomedicine
5' Untranslated Regions
Parechovirus B
Subjects
Details
- ISSN :
- 19994915
- Volume :
- 13
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Viruses
- Accession number :
- edsair.doi.dedup.....8930008a43ff5f51dcea0ce847f794e2