Toxicological evaluations of methanolic extract of Moringa oleifera leaves in liver and kidney of male Wistar rats

BACKGROUND: This study was conducted to investigate toxicological effects associated with prolonged consumption of Moringa oleifera leaves as a beverage. METHODS: Thirty rats were used in this study. They were grouped into five groups of six rats. Rats in group I received 2 mL/kg body weight (b.w.) of corn oil (vehicle). Animals in groups II, III, IV and V received 50, 100, 200 and 400 mg/kg b.w. of methanolic extract of M. oleifera (MEMO) for 8 weeks. Serum collected was analyzed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein, albumin, globulin, blood urea nitrogen (BUN) and creatinine. RESULTS: There was a significant (p