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Determination of Aromatic Amines Released from Azo Dyes in Paper Packaging by Liquid Chromatography-Tandem Mass Spectrometry
- Source :
- Journal of AOAC INTERNATIONAL. 99:1370-1376
- Publication Year :
- 2016
- Publisher :
- Oxford University Press (OUP), 2016.
-
Abstract
- An LC-tandem MS (LC–MS/MS) method for the determination of 21 kinds of carcinogenic aromatic amines released from azo dyes in food wrappers was used in this research. Sodium dithionite was added to a citric acid buffer medium to reduce and decompose possible azo dyes. The extract was analyzed after liquid–liquid extraction (LLE) and dispersive SPE (d-SPE). The conditions for chromatographic separation, mass spectrum, LLE, and d-SPE were optimized. Under optimal conditions, the LOD was in the range of 0.13–0.35 mg/kg and LOQ in the range of 0.38–1.05 mg/kg, with the addition of standard recoveries of most aromatic amines being ≥80% and RSDs ≤10%. The recoveries for 2,4-diaminotoluene and 2,4-diaminoanisole were significantly lower, being ≤40%. The method was successfully used to analyze 30 practical samples, and the results showed that it is user-friendly, with high sensitivity, rapid control, and low matrix interference.
- Subjects :
- Paper
02 engineering and technology
Tandem mass spectrometry
01 natural sciences
Analytical Chemistry
Sodium dithionite
chemistry.chemical_compound
Tandem Mass Spectrometry
Liquid chromatography–mass spectrometry
Environmental Chemistry
Amines
Coloring Agents
Pharmacology
Chromatography
010401 analytical chemistry
Extraction (chemistry)
Food Packaging
021001 nanoscience & nanotechnology
0104 chemical sciences
Food packaging
Chromatographic separation
chemistry
Mass spectrum
0210 nano-technology
Citric acid
Azo Compounds
Agronomy and Crop Science
Chromatography, Liquid
Food Science
Subjects
Details
- ISSN :
- 19447922 and 10603271
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Journal of AOAC INTERNATIONAL
- Accession number :
- edsair.doi.dedup.....894d58e4a34054af420e68139c4db865