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Laminin-111 Improves the Anabolic Response to Mechanical Load in Aged Skeletal Muscle
- Source :
- J Gerontol A Biol Sci Med Sci
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Anabolic resistance to a mechanical stimulus may contribute to the loss of skeletal muscle mass observed with age. In this study, young and aged mice were injected with saline or human LM-111 (1 mg/kg). One week later, the myotendinous junction of the gastrocnemius muscle was removed via myotenectomy (MTE), thus placing a chronic mechanical stimulus on the remaining plantaris muscle for 2 weeks. LM-111 increased α7B integrin protein expression and clustering of the α7B integrin near DAPI+ nuclei in aged muscle in response to MTE. LM-111 reduced CD11b+ immune cells, enhanced repair, and improved the growth response to loading in aged plantaris muscle. These results suggest that LM-111 may represent a novel therapeutic approach to prevent and/or treat sarcopenia.
- Subjects :
- 0301 basic medicine
Integrins
Sarcopenia
THE JOURNAL OF GERONTOLOGY: Biological Sciences
Aging
medicine.medical_specialty
Anabolism
Muscle hypertrophy
Mice
03 medical and health sciences
chemistry.chemical_compound
Gastrocnemius muscle
Anabolic Agents
0302 clinical medicine
Physical Conditioning, Animal
Internal medicine
Animals
Regeneration
Medicine
DAPI
Muscle, Skeletal
biology
business.industry
Skeletal muscle
medicine.disease
Extracellular Matrix
030104 developmental biology
medicine.anatomical_structure
Endocrinology
Integrin alpha M
chemistry
biology.protein
Laminin
Plantaris muscle
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1758535X and 10795006
- Volume :
- 76
- Database :
- OpenAIRE
- Journal :
- The Journals of Gerontology: Series A
- Accession number :
- edsair.doi.dedup.....895deec7083669b4f52689c765fdaf65