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Adverse events as potential predictive factors of activity in patients with advanced hepatocellular carcinoma treated with lenvatinib
- Publication Year :
- 2021
-
Abstract
- Background and Aim: Lenvatinib is a standard of care option in first-line therapy of advanced hepatocellular carcinoma (HCC). In the present study, we aim to identify, in patients with HCC treated with lenvatinib, a possible association between occurrence and grading of adverse events (AEs) and outcome. Methods: We performed a retrospective analysis of 606 Japanese and Italian patients treated with lenvatinib in first-line setting and investigated the possible correlation between the onset of AEs, toxicity grade (G) and outcome measures such as overall survival (OS) and progression-free survival (PFS). Results: The appearance of arterial hypertension G≥2 independently predicted prolonged OS [hazard ratio (HR) 0.66, 95% confidence interval (CI) 0.46–0.93, P=.0188], whereas decreased appetite G≥2 independently predicted decreased OS (HR 1.70, 95% CI 1.25–2.32, P=.0007) by multivariate analysis. Appearance of hand-foot skin reaction independently predicted prolonged PFS (HR 0.72, 95% CI 0.56–0.93, P=.0149), whereas decreased appetite G≥2 predicted decreased PFS (HR 1.36, 95% CI 1.04–1.77, P=.0277). Conclusions: Our main findings are that the occurrence of arterial hypertension G≥2 is a predictor of longer survival, whereas decreased appetite G≥2 predicts for a poor prognosis. A careful management of AEs under lenvatinib treatment for HCC is required, to improve patients’ quality of life, minimize the need for treatment discontinuation and achieve optimal outcome.
- Subjects :
- Phenylurea Compound
medicine.medical_specialty
Carcinoma, Hepatocellular
Multivariate analysis
predictive factors
adverse event
lenvatinib
Gastroenterology
predictive factor
chemistry.chemical_compound
Quality of life
Internal medicine
medicine
Humans
Adverse effect
Retrospective Studies
adverse events
hepatocellular carcinoma
Settore MED/12 - Gastroenterologia
Hepatology
business.industry
Phenylurea Compounds
Liver Neoplasms
Hazard ratio
medicine.disease
Confidence interval
Discontinuation
chemistry
Liver Neoplasm
Hepatocellular carcinoma
Quality of Life
Quinolines
Lenvatinib
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....8966b5e869f2f936d9d9f6ae61f443d0