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Cell Cycle-Dependent Induction of Autophagy, Mitophagy and Reticulophagy
- Source :
- Scopus-Elsevier
- Publication Year :
- 2007
- Publisher :
- Informa UK Limited, 2007.
-
Abstract
- When added to cells, a variety of autophagy inducers that operate through distinct mechanisms and target different organelles for autophagic destruction (mitochondria in mitophagy, endoplasmic reticulum in reticulophagy) rarely induce autophagic vacuolization in more than 50% or the cells. Here we show that this heterogeneity may be explained by cell cycle-specific effects. The BH3 mimetic ABT737, lithium, rapamycin, tunicamycin or nutrient depletion stereotypically induce autophagy preferentially in the G(1) and S phases of the cell cycle, as determined by simultaneous monitoring of cell cycle markers and the cytoplasmic aggregation of GFP-LC3 in autophagic vacuoles. These results point to a hitherto neglected crosstalk between autophagic vacuolization and cell cycle regulation.
- Subjects :
- Cell Cycle
Reticulophagy
Autophagy
Apoptosis
Cell Differentiation
Cell Biology
Tunicamycin
Vacuole
Cell cycle
Biology
Endoplasmic Reticulum
HCT116 Cells
Mitochondria
Rats
Cell biology
chemistry.chemical_compound
chemistry
Vacuolization
Cytoplasm
Mitophagy
Animals
Humans
Molecular Biology
Developmental Biology
Subjects
Details
- ISSN :
- 15514005 and 15384101
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Cell Cycle
- Accession number :
- edsair.doi.dedup.....8976f68f328c923c5316d01fb4d19b93