Back to Search
Start Over
DNMT3A mutation is associated with increased age and adverse outcome in adult T-acute lymphoblastic leukemia
- Source :
- Haematologica, Haematologica, 2019, 104 (8), pp.1617-1625. ⟨10.3324/haematol.2018.197848⟩, Haematologica, Ferrata Storti Foundation, 2019, 104 (8), pp.1617-1625. ⟨10.3324/haematol.2018.197848⟩, Haematologica, Vol. 104, no. 8, p. 1617-1625 (2019), Haematologica, Vol. 104, No 8 (2019) pp. 1617-1625
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- The prognostic implications of DNMT3A genotype in T-cell acute lymphoblastic leukemia are incompletely understood. We performed comprehensive genetic and clinico-biological analyses of T-cell acute lymphoblastic leukemia patients with DNMT3A mutations treated during the GRAALL-2003 and -2005 studies. Eighteen of 198 cases (9.1%) had DNMT3A alterations. Two patients also had DNMT3A mutations in non-leukemic cell DNA, providing the first potential evidence of age-related clonal hematopoiesis in T-cell acute lymphoblastic leukemia. DNMT3A mutation was associated with older age (median 43.9 years vs. 29.4 years, P
- Subjects :
- Oncology
medicine.medical_specialty
Adverse outcomes
[SDV]Life Sciences [q-bio]
Cell
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Text mining
Internal medicine
Genotype
medicine
Adult Acute
ddc:616
Cytogenetics and Molecular Genetics
business.industry
Hematology
Acute Lymphoblastic Leukemia
Prognosis
3. Good health
[SDV] Life Sciences [q-bio]
Adult Acute Lymphoblastic Leukemia
Institutional repository
medicine.anatomical_structure
chemistry
Adult T-Cell Acute Lymphoblastic Leukemia
Mutation (genetic algorithm)
embryonic structures
Lymphoblastic Leukemia
DNMT3A
business
DNA
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 03906078 and 15928721
- Database :
- OpenAIRE
- Journal :
- Haematologica, Haematologica, 2019, 104 (8), pp.1617-1625. ⟨10.3324/haematol.2018.197848⟩, Haematologica, Ferrata Storti Foundation, 2019, 104 (8), pp.1617-1625. ⟨10.3324/haematol.2018.197848⟩, Haematologica, Vol. 104, no. 8, p. 1617-1625 (2019), Haematologica, Vol. 104, No 8 (2019) pp. 1617-1625
- Accession number :
- edsair.doi.dedup.....89786841cb0982215a133d6e266f164d