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Systemic conditions associated with increased risk to develop oral squamous cell carcinoma: Systematic review and meta‐analysis

Systemic conditions associated with increased risk to develop oral squamous cell carcinoma: Systematic review and meta‐analysis

Authors :
Erison Santana Dos Santos
Maria Eduarda Pérez‐de‐Oliveira
Ana Gabriela Costa Normando
Luiz Alcino Monteiro Gueiros
Silvia Regina Rogatto
Pablo Agustin Vargas
Márcio Ajudarte Lopes
Eliete Neves da Silva Guerra
Adriana Franco Paes Leme
Alan Roger Santos‐Silva
Source :
Head & Neck. 44:2925-2937
Publication Year :
2022
Publisher :
Wiley, 2022.

Abstract

This study aimed to map systemic alterations predisposing to oral squamous cell carcinoma (OSCC) onset. This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Five databases were used to access (1) reports of OSCC co-occurring in patients with systemic conditions, (2) prevalence of OSCC among these patients, and (3) clinicopathological profiles. Data from more than 1 million patients worldwide showed that Fanconi's anemia, xeroderma pigmentosum, dyskeratosis congenital, chronic fatigue syndrome, and patients post bone marrow transplantation (BMT) present increased risk for OSCC development. The overall prevalence of OSCC in syndromic patients and post-BMT were 0.65% (95% CI = 0.13-3.11, p 0.01) and 5.83% (95% CI = 0.00-30.90, p 0.01), respectively. The certainty of the evidence was moderate. This study demonstrated that some systemic conditions predispose to OSCC. These results present an impact on the screening of OSCC in systemically compromised patients.

Details

ISSN :
10970347 and 10433074
Volume :
44
Database :
OpenAIRE
Journal :
Head & Neck
Accession number :
edsair.doi.dedup.....899c2535b3526bca2b6246704af285ca
Full Text :
https://doi.org/10.1002/hed.27193