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A possible new focus for stroke treatment – migrating stem cells
- Source :
- Expert Opinion on Biological Therapy. 15:949-958
- Publication Year :
- 2015
- Publisher :
- Informa Healthcare, 2015.
-
Abstract
- Stroke is a leading cause of mortality in the US. More so, its infliction often leaves patients with lasting morbidity and deficits. Ischemic stroke comprises nearly 90% of incidents and the majority of medical treatment aims at reestablishing perfusion and preventing recurrence.Long-term options for neurorestoration are limited by the infancy of their innovative approach. Accumulating evidence suggests the therapeutic potential of stem cells in neurorestoration, however, proper stem cell migration remains a challenge in translating stem cell therapy from the laboratory to the clinic. In this paper, we propose the role that exogenous stem cell transplantation may serve in facilitating the migration of endogenous stem cells to the site of injury, an idea termed 'biobridge'.Recent research in the field of traumatic brain injury has provided a foundational understanding that, through the use of exogenous stem cells, native tissue architecture may be manipulated by proteinases to allow better communication between the endogenous sites of neural stem cells and the regions of injury. There is still much to be learned about these mechanisms, though it is the devastating nature of stroke that necessitates continued research into the prospective therapeutic potential of this novel approach.
- Subjects :
- medicine.medical_treatment
Clinical Biochemistry
Clinical uses of mesenchymal stem cells
Bone Marrow Cells
Bioinformatics
Article
Neural Stem Cells
Cell Movement
Drug Discovery
medicine
Humans
Progenitor cell
Endothelial Progenitor Cells
Stem cell transplantation for articular cartilage repair
Pharmacology
business.industry
Cell Differentiation
Mesenchymal Stem Cells
Stem-cell therapy
Hematopoietic Stem Cells
Matrix Metalloproteinases
Neural stem cell
Stroke
Transplantation
Immunology
Stem cell
business
Stem Cell Transplantation
Adult stem cell
Subjects
Details
- ISSN :
- 17447682 and 14712598
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Expert Opinion on Biological Therapy
- Accession number :
- edsair.doi.dedup.....899d0bf53d30b05a1cc2bab45c1ea6c3