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History of extracardiac/cardiac events in cardiac amyloidosis: prevalence and time from initial onset to diagnosis
- Source :
- ESC Heart Failure, ESC Heart Failure, Vol 8, Iss 6, Pp 5501-5512 (2021)
- Publication Year :
- 2021
- Publisher :
- John Wiley and Sons Inc., 2021.
-
Abstract
- Aims Cardiac amyloidosis (CA) has a poor prognosis which is aggravated by diagnostic delay. Amyloidosis extracardiac and cardiac events (AECE and ACE) may help improve CA diagnosis and typing. The aim of this study was to compare AECE and ACE between different CA types and assess their relationship with survival. Methods and results This retrospective cohort study conducted in France from June 2008 to May 2019, at the Henry Mondor Hospital. This cohort included 983 patients with CA. Mean age at inclusion was 73.1 ± 11.4 years, 726 (75.1%) were male and the mean body mass index was 24.5 ± 4.1 kg/m2. Among them, 321 had immunoglobulin light chain (AL) amyloidosis, 434 had wild‐type transthyretin (ATTRwt), and 212 had hereditary transthyretin (ATTRv). The first AECE and/or ACE occurred at a mean age of 63 ± 11 years for AL and ATTRv, and 70 ± 12 years for ATTRwt (P
- Subjects :
- Male
medicine.medical_specialty
Delayed Diagnosis
Cardiac amyloidosis
Transthyretin
Internal medicine
medicine
Prevalence
Diseases of the circulatory (Cardiovascular) system
Humans
Immunoglobulin Light-chain Amyloidosis
Survival rate
Integumentary
Retrospective Studies
biology
business.industry
Amyloidosis
Retrospective cohort study
Original Articles
medicine.disease
AL
RC666-701
Heart failure
Cohort
Symptoms
Cardiology
biology.protein
Original Article
Cardiology and Cardiovascular Medicine
business
Body mass index
Subjects
Details
- Language :
- English
- ISSN :
- 20555822
- Volume :
- 8
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- ESC Heart Failure
- Accession number :
- edsair.doi.dedup.....89ac09fd9077a1cbdae0515794525e36