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Apolipoprotein E, Cognitive Function, and Dementia in a General Population Aged 85 Years and Over
- Source :
- International Psychogeriatrics. 12:379-387
- Publication Year :
- 2000
- Publisher :
- Cambridge University Press (CUP), 2000.
-
Abstract
- We examined 510 subjects representing 83.2% of all citizens of a Finnish city aged 85 years or over. Mini-Mental State Examination (MMSE) scores, diagnosis of dementia by DSM-III-R criteria, and Apo-E genotype were determined. The prevalence of dementia was 38.6%. The odds ratio (OR) of the Apo-E ε4 carriers (with the reference population of people with the genotype ε3/ε3) for dementia was 2.36 (95% CI 1.58–3.58). There was a significant sex difference: The OR in women was 3.23 (95% CI 2.02–5.17) whereas among men it was insignificant. The mean MMSE score (± SD) among the Apo-E ε4 carriers (15.0 ± 10.0) and noncarriers (18.7 ± 8.6) (p < .001) differed among the whole population, but not within the demented or nondemented subjects analyzed separately. This study does not support the hypothesis that the Apo-E ε4 allele impairs cognitive functions of nondemented elderly, at least in those surviving to very old age.
- Subjects :
- Male
Gerontology
Apolipoprotein E
Genotype
Population
Neuropsychological Tests
Severity of Illness Index
050105 experimental psychology
03 medical and health sciences
Age Distribution
Apolipoproteins E
0302 clinical medicine
Catchment Area, Health
medicine
Humans
Dementia
0501 psychology and cognitive sciences
Reference population
Sex Distribution
education
Alleles
Finland
Aged
Aged, 80 and over
education.field_of_study
05 social sciences
Cognitive disorder
Cognition
Odds ratio
medicine.disease
Psychiatry and Mental health
Clinical Psychology
Population Surveillance
Female
Geriatrics and Gerontology
Cognition Disorders
Psychology
030217 neurology & neurosurgery
Demography
Subjects
Details
- ISSN :
- 1741203X and 10416102
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- International Psychogeriatrics
- Accession number :
- edsair.doi.dedup.....89b432800e3b17b579abc2b8bd0b34cb