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Natural iridoids from Patrinia heterophylla showing anti-inflammatory activities in vitro and in vivo
- Source :
- Bioorganic Chemistry. 104:104331
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Inflammation, especially chronic inflammation, has been found to be closely related to the pathology of many diseases and the discovery of bioactive natural products to inhibit NO production is one of strategies to treat inflammation. In our continuous search for bioactive natural substances as potential anti-inflammatory agents, five new compounds (1-5) were extracted and purified from Patrinia heterophylla. The NMR and MS data analysis, along with electronic circular dichroism (ECD) calculations, led to the identification of these isolates, which were new iridoids. Using cell and zebrafish models, the in vitro and in vivo anti-inflammatory effects were conducted to evaluate the potency of anti-inflammation of these compounds. The preliminary mechanism was explored using molecular docking and Western blotting experiments.
- Subjects :
- Circular dichroism
Cell Survival
medicine.drug_class
Cell
Inflammation
Nitric Oxide
01 natural sciences
Biochemistry
Anti-inflammatory
Mice
Structure-Activity Relationship
In vivo
Drug Discovery
medicine
Animals
Potency
Iridoids
Molecular Biology
Zebrafish
Patrinia
Biological Products
Dose-Response Relationship, Drug
Molecular Structure
010405 organic chemistry
Chemistry
Anti-Inflammatory Agents, Non-Steroidal
Organic Chemistry
In vitro
0104 chemical sciences
Molecular Docking Simulation
Blot
010404 medicinal & biomolecular chemistry
medicine.anatomical_structure
medicine.symptom
Reactive Oxygen Species
Subjects
Details
- ISSN :
- 00452068
- Volume :
- 104
- Database :
- OpenAIRE
- Journal :
- Bioorganic Chemistry
- Accession number :
- edsair.doi.dedup.....89cd9a55c31e902827960af4eec12f1d