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Relation of High-Sensitivity Troponin to 1 Year Mortality in 20,000 Consecutive Hospital Patients Undergoing a Blood Test for Any Reason
- Source :
- The American Journal of Cardiology. 158:124-131
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- This was an observational study of the 1-year outcomes of the 20,000 patients included in the original CHARIOT study. The aim of the study was to assess the association between high sensitivity troponin I (hs-cTnI) concentration and 1 year mortality in this cohort. The original CHARIOT study included a consecutive cohort of in- and out-patients undergoing blood tests for any reason. Hs-cTnI concentrations were measured regardless of whether the clinician requested them. These results were nested and not revealed to the team unless requested for clinical reasons. One year mortality data was obtained from NHS Digital as originally planned. Overall, 1782 (8.9%) patients had died at 1 year. Multivariable Cox regression analysis showed that a hs-cTnI concentration above the upper limit of normal was independently associated with the hazard of mortality (HR 2.23; 95% confidence intervals 1.97 to 2.52). Furthermore, the log (10) hs-cTnI concentration was independently associated with the hazard of 1 year mortality (HR 1.77; 95% confidence intervals 1.64 to 1.91). In conclusion, in a large, unselected hospital population of both in- and out-patients, in 18,282 (91.4%) of whom there was no clinical indication for testing, hs-cTnI concentration was associated with 1 year mortality.
- Subjects :
- Adult
Male
medicine.medical_specialty
Kaplan-Meier Estimate
Internal medicine
medicine
Humans
Blood test
Hospital patients
Aged
Proportional Hazards Models
Aged, 80 and over
medicine.diagnostic_test
business.industry
Proportional hazards model
Troponin I
Middle Aged
Confidence interval
Hospitalization
Survival Rate
Cardiovascular Diseases
High sensitivity troponin
Cohort
Cardiology
Female
Observational study
Cardiology and Cardiovascular Medicine
1 year mortality
business
Biomarkers
Subjects
Details
- ISSN :
- 00029149
- Volume :
- 158
- Database :
- OpenAIRE
- Journal :
- The American Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....89fefed3f5264cd58a6fe0c4e9510592