Back to Search
Start Over
An unusual case of amoxicillin/clavulanic acid-related hepatotoxicity
- Source :
- The American journal of gastroenterology. 93(8)
- Publication Year :
- 1998
-
Abstract
- Amoxicillin/clavulanic acid is a widely used antibiotic. Hepatic dysfunction is a rare adverse reaction associated with this combination antibiotic. We report the case of a 40-yr-old woman with a somewhat unusual presentation of amoxicillin/clavulanate-related cholestatic hepatotoxicity and multiple duodenal erosions whose diagnosis was delayed until inadvertent rechallenge with the antibiotic combination. The relevant literature is also reviewed and discussed. The diagnosis may be missed because the onset of signs/symptoms may occur several weeks after the cessation of therapy. The hepatic dysfunction, which may be severe and is more prevalent in elderly patients, is usually reversible, although chronic liver disease and deaths have been reported. Immunological hypersensitivity is considered to be the most likely mechanism resulting in liver injury. Amoxicillin/clavulanate should be used with caution in patients with underlying liver disease and in the elderly.
- Subjects :
- Adult
medicine.medical_specialty
medicine.drug_class
Antibiotics
Chronic liver disease
Amoxicillin-Potassium Clavulanate Combination
Gastroenterology
Liver disease
Recurrence
Clavulanic acid
Internal medicine
medicine
Humans
Sinusitis
Adverse effect
Antibacterial agent
Amoxicillin/clavulanic acid
Cholestasis
Hepatology
business.industry
Amoxicillin
medicine.disease
Immunology
Acute Disease
Drug Therapy, Combination
Female
Chemical and Drug Induced Liver Injury
business
medicine.drug
Subjects
Details
- ISSN :
- 00029270
- Volume :
- 93
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- The American journal of gastroenterology
- Accession number :
- edsair.doi.dedup.....8a009b2e66c82b94f2326d064ec72e9e