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Wastewater Surveillance of SARS-CoV-2 across 40 U.S. states
- Source :
- medRxiv, article-version (status) pre, article-version (number) 2
- Publication Year :
- 2021
- Publisher :
- Cold Spring Harbor Laboratory, 2021.
-
Abstract
- Wastewater-based disease surveillance is a promising approach for monitoring community outbreaks. Here we describe a nationwide campaign to monitor SARS-CoV-2 in the wastewater of 159 counties in 40 U.S. states, covering 13% of the U.S. population from February 18 to June 2, 2020. Out of 1,751 total samples analyzed, 846 samples were positive for SARS-CoV-2 RNA, with overall viral concentrations declining from April to May. Wastewater viral titers were consistent with, and appeared to precede, clinical COVID-19 surveillance indicators, including daily new cases. Wastewater surveillance had a high detection rate (>80%) of SARS-CoV-2 when the daily incidence exceeded 13 per 100,000 people. Detection rates were positively associated with wastewater treatment plant catchment size. To our knowledge, this work represents the largest-scale wastewater-based SARS-CoV-2 monitoring campaign to date, encompassing a wide diversity of wastewater treatment facilities and geographic locations. Our findings demonstrate that a national wastewater-based approach to disease surveillance may be feasible and effective.
- Subjects :
- education.field_of_study
Disease surveillance
Coronavirus disease 2019 (COVID-19)
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Incidence (epidemiology)
Population
Outbreak
COVID-19
Wastewater
Article
Disease Outbreaks
Environmental health
Environmental science
Humans
RNA, Viral
Sewage treatment
education
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- medRxiv
- Accession number :
- edsair.doi.dedup.....8a155f01855da39f7283229f03891d70