Role of Glucagon and Adrenergic Receptors in Thyrocalcitonin Release in the Dog

Data obtained in the dog during thyroid perfusion support the hypothesis that glucagon and epinephrine stimulate thyrocalcitonin release via adenyl cyclase activation and consequently by the intracellular level of cyclic adenosine monophosphate. The studies also suggest that agonists acting at alpha adrenergic loci may lead to a reduction in cyclic adenosine monophosphate in the parafollicular thyroid cells. (Endocrinology 88: 1337, 1971)