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[Paracoccidioidomycosis (South American blastomycosis): treatment with miconazole]
- Source :
- Boletin de la Oficina Sanitaria Panamericana. Pan American Sanitary Bureau. 87(1)
- Publication Year :
- 1979
-
Abstract
- Six patients with multisystem paracoccidioidomycosis proven by serology and culture or smear were treated with relatively brief courses of intravenous miconazole. Two had relapsed following prior therapy; 6 had active pulmonary, 4 laryngeal, 2 oropharyngeal, 2 lymphoid, and 1 abdominal disease. Paracoccidioides brasiliensis was highly susceptible to miconazole in vitro; minimal inhibitory concentration was less than or equal to 0.001 microgram/ml. Clinical examination showed a prompt and objective response in all patients, confirmed by smear or culture and X-rays; in 4/6 serological response was shown. Side effects were minor. Two patients relapsed 3--5 mo after therapy; another had a rise in antibody 6 mo after therapy and was given maintenance oral sulfa. One remains in remission 7 mo after treatment; two given oral sulfa after response to miconazole remain in remission 4--6 mo after treatment. Paracoccidioidomycosis responds well to miconazole, but longer courses may be needed to prevent relapse.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Miconazole
Gastroenterology
Serology
Blood serum
Virology
Internal medicine
Amphotericin B
Medicine
Humans
Paracoccidioides brasiliensis
biology
business.industry
Paracoccidioidomycosis
Imidazoles
Middle Aged
medicine.disease
biology.organism_classification
Infectious Diseases
Blood chemistry
Evaluation Studies as Topic
Immunology
Drug Evaluation
Parasitology
business
Blastomycosis
medicine.drug
Subjects
Details
- ISSN :
- 00300632
- Volume :
- 87
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Boletin de la Oficina Sanitaria Panamericana. Pan American Sanitary Bureau
- Accession number :
- edsair.doi.dedup.....8a247e6c215e84e144222d4dcb7d883e