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The Triple HIT: Perioperative Management of Heparin-Induced Thrombocytopenia Using Plasma Exchange, Intravenous Immunoglobulin, and Protamine Infusion for Left Ventricular Assist Device Implantation
- Source :
- Journal of Cardiothoracic and Vascular Anesthesia. 36:1715-1719
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Heparin-induced thrombocytopenia (HIT) is a serious complication in patients exposed to heparin, leading to thrombocytopenia and, potentially, thrombosis. This disorder is challenging in cardiac surgery when anticoagulation for cardiopulmonary bypass is required. Herein a patient with HIT who had active thrombosis and successfully underwent urgent left ventricular assist device implantation managed with plasma exchange, intravenous immunoglobulin, and protamine infusion is described. These therapies reduce the immune response to heparin and minimize thrombosis when heparin reexposure is planned. These approaches to perioperative management of HIT represent an attractive alternative to the use of non-heparin anticoagulants in the cardiac and vascular surgical population.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Population
030204 cardiovascular system & hematology
law.invention
03 medical and health sciences
0302 clinical medicine
030202 anesthesiology
law
Heparin-induced thrombocytopenia
medicine
Cardiopulmonary bypass
Humans
Protamines
education
education.field_of_study
Plasma Exchange
biology
Heparin
business.industry
Anticoagulants
Immunoglobulins, Intravenous
Thrombosis
medicine.disease
Thrombocytopenia
Protamine
Cardiac surgery
Anesthesiology and Pain Medicine
Ventricular assist device
Anesthesia
biology.protein
Heart-Assist Devices
Cardiology and Cardiovascular Medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 10530770
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of Cardiothoracic and Vascular Anesthesia
- Accession number :
- edsair.doi.dedup.....8a2b9bb4a543a396a28c2d6cb210eec3