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Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors
- Source :
- Bioorganic & Medicinal Chemistry Letters. 16:2996-2999
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 microM in vitro and showed a reduced invasion in cell-based assay.
- Subjects :
- Rhodanine
Clinical Biochemistry
Pharmaceutical Science
Naphthalenes
Biochemistry
Chemical synthesis
Mice
Structure-Activity Relationship
chemistry.chemical_compound
Cell Line, Tumor
Drug Discovery
Animals
Humans
Structure–activity relationship
Enzyme Inhibitors
Molecular Biology
IC50
chemistry.chemical_classification
Aldehydes
Molecular Structure
biology
Organic Chemistry
Biological activity
In vitro
Enzyme
chemistry
Enzyme inhibitor
biology.protein
Molecular Medicine
Protein Tyrosine Phosphatases
Protein Binding
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....8a3c1ecfb244cf5a5dfd803ebac06c4d