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The use of hypromellose in oral drug delivery
- Source :
- Journal of Pharmacy and Pharmacology. 57:533-546
- Publication Year :
- 2005
- Publisher :
- Oxford University Press (OUP), 2005.
-
Abstract
- Hypromellose, formerly known as hydroxypropylmethylcellulose (HPMC), is by far the most commonly employed cellulose ether used in the fabrication of hydrophilic matrices. Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect. This review provides a current insight into hypromellose and its applicability to hydrophilic matrices in order to highlight the basic parameters that affect its performance. Topics covered include the chemical, thermal and mechanical properties of hypromellose, hydration of the polymer matrices, the mechanism of drug release and the influence of tablet geometry on drug-release rate. The inclusion of drug-release modifiers within hypromellose matrices, the effects of dissolution media and the influence of both the external environment and microenvironment pH within the gel matrix on the properties of the polymer are also discussed.
- Subjects :
- Pharmacology
chemistry.chemical_classification
Drug Carriers
Viscosity
Gel matrix
Hydrophilic matrix
Administration, Oral
Pharmaceutical Science
Capsules
Polymer
Methylcellulose
Polyvinyl alcohol
Hypromellose Derivatives
chemistry.chemical_compound
Drug Stability
Solubility
chemistry
Chemical engineering
Tensile Strength
Drug release
Particle Size
Oral retinoid
Subjects
Details
- ISSN :
- 20427158 and 00223573
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacy and Pharmacology
- Accession number :
- edsair.doi.dedup.....8a5bc8d8e25132a898a9bc148456643e