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Identification of Genes Encoding Antimicrobial Proteins in Langerhans Cells
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Vol 12 (2021)
- Publication Year :
- 2021
- Publisher :
- eScholarship, University of California, 2021.
-
Abstract
- Langerhans cells (LCs) reside in the epidermis where they are poised to mount an antimicrobial response against microbial pathogens invading from the outside environment. To elucidate potential pathways by which LCs contribute to host defense, we mined published LC transcriptomes deposited in GEO and the scientific literature for genes that participate in antimicrobial responses. Overall, we identified 31 genes in LCs that encode proteins that contribute to antimicrobial activity, ten of which were cross-validated in at least two separate experiments. Seven of these ten antimicrobial genes encode chemokines,CCL1, CCL17, CCL19, CCL2, CCL22, CXCL14andCXCL2, which mediate both antimicrobial and inflammatory responses. Of these,CCL22was detected in seven of nine transcriptomes and by PCR in cultured LCs. Overall, the antimicrobial genes identified in LCs encode proteins with broad antibacterial activity, including againstStaphylococcus aureus, which is the leading cause of skin infections. Thus, this study illustrates that LCs, consistent with their anatomical location, are programmed to mount an antimicrobial response against invading pathogens in skin.
- Subjects :
- Chemokine
Staphylococcus aureus
skin
Cells
Antimicrobial peptides
Immunology
CCL1
Biology
medicine.disease_cause
Microbiology
Transcriptome
Databases
antimicrobial peptides
Genetic
Clinical Research
Databases, Genetic
medicine
Genetics
Immunology and Allergy
Humans
2.1 Biological and endogenous factors
Langerhans cells
dendritic cells
Aetiology
Gene
Cells, Cultured
Original Research
Cultured
Epidermis (botany)
integumentary system
Gene Expression Profiling
bioinformatics
RC581-607
Antimicrobial
immunity
Emerging Infectious Diseases
Medical Microbiology
Langerhans Cells
Host-Pathogen Interactions
biology.protein
Staphylococcal Skin Infections
Immunologic diseases. Allergy
Epidermis
Infection
transcriptome
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology, Frontiers in Immunology, Vol 12 (2021)
- Accession number :
- edsair.doi.dedup.....8a6a1e7a74818d6221d363c8bd29bdd1