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Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice
- Source :
- PLoS ONE, Vol 15, Iss 12, p e0239246 (2020), PLoS ONE
- Publication Year :
- 2020
- Publisher :
- Public Library of Science (PLoS), 2020.
-
Abstract
- Alcohol use disorder (AUD) is a chronic relapsing disorder characterized by an impaired ability to stop or control alcohol use despite adverse social, occupational, or health consequences. AUD is associated with a variety of physiological changes and is a substantial risk factor for numerous diseases. We aimed to characterize systemic alterations in immune responses using a mouse model of chronic intermittent alcohol exposure to induce alcohol dependence. We exposed mice to chronic intermittent ethanol vapor for 4 weeks and used multiparametric flow cytometry to analyze the expression of cytokines IFN-γ, IL-4, IL-10, IL-12 and IL-17 by different immune cells in the blood, spleen and liver of alcohol dependent and non-dependent control mice. We found increases in IFN-γ and IL-17 expression in a cell type- and organ-specific manner. Often, B cells and neutrophils are primary contributors to increased IFN-γ and IL-17 levels while other cell types play a secondary role. We conclude that chronic alcohol exposure promotes systemic pro-inflammatory IFN-γ and IL-17 responses in mice. These responses are likely important in the development of alcohol-related diseases, but further characterization is necessary to understand the initiation and effects of systemic inflammatory responses to chronic alcohol exposure.
- Subjects :
- Male
0301 basic medicine
B Cells
Neutrophils
Physiology
Social Sciences
Alcohol use disorder
White Blood Cells
Mice
chemistry.chemical_compound
0302 clinical medicine
Animal Cells
Immune Physiology
Medicine and Health Sciences
Psychology
Public and Occupational Health
Innate Immune System
Multidisciplinary
medicine.diagnostic_test
T Cells
Organic Compounds
Interleukin-17
Alcoholism
Chemistry
medicine.anatomical_structure
Liver
Physical Sciences
Cytokines
Medicine
030211 gastroenterology & hepatology
Interleukin 17
Cellular Types
Research Article
Cell type
Substance-Related Disorders
Immune Cells
Science
Immunology
Addiction
Spleen
Flow cytometry
Interferon-gamma
03 medical and health sciences
Immune system
Mental Health and Psychiatry
medicine
Animals
Antibody-Producing Cells
Blood Cells
Ethanol
business.industry
Macrophages
Organic Chemistry
Alcohol dependence
Chemical Compounds
Biology and Life Sciences
Cell Biology
Molecular Development
medicine.disease
030104 developmental biology
chemistry
Immune System
Alcohols
business
Developmental Biology
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....8a7adc11e8a47c0cf31e71d246d56359