Back to Search
Start Over
HepatoScoreā14: Measures of Biological Heterogeneity Significantly Improve Prediction of Hepatocellular Carcinoma Risk
- Source :
- Hepatology
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- BACKGROUND AND AIMS Therapeutic, clinical trial entry and stratification decisions for hepatocellular carcinoma (HCC) are made based on prognostic assessments, using clinical staging systems based on small numbers of empirically selected variables that insufficiently account for differences in biological characteristics of individual patients' disease. APPROACH AND RESULTS We propose an approach for constructing risk scores from circulating biomarkers that produce a global biological characterization of individual patient's disease. Plasma samples were collected prospectively from 767 patients with HCC and 200 controls, and 317 proteins were quantified in a Clinical Laboratory Improvement Amendments-certified biomarker testing laboratory. We constructed a circulating biomarker aberration score for each patient, a score between 0 and 1 that measures the degree of aberration of his or her biomarker panel relative to normal, which we call HepatoScore. We used log-rank tests to assess its ability to substratify patients within existing staging systems/prognostic factors. To enhance clinical application, we constructed a single-sample score, HepatoScore-14, which requires only a subset of 14 representative proteins encompassing the global biological effects. Patients with HCC were split into three distinct groups (low, medium, and high HepatoScore) with vastly different prognoses (medial overall survival 38.2/18.3/7.1 months; P
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Hepatology
business.industry
MEDLINE
Biomarker panel
Therapeutic decision making
Disease
medicine.disease
Article
3. Good health
Biomarker (cell)
Clinical trial
03 medical and health sciences
Circulating biomarkers
030104 developmental biology
0302 clinical medicine
Hepatocellular carcinoma
Internal medicine
medicine
030211 gastroenterology & hepatology
business
Subjects
Details
- ISSN :
- 15273350 and 02709139
- Volume :
- 73
- Database :
- OpenAIRE
- Journal :
- Hepatology
- Accession number :
- edsair.doi.dedup.....8a86f6d8d389bc307e38270a1313a866