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The Bidirectional Link Between Sleep Disturbances and Traumatic Brain Injury Symptoms: A Role for Glymphatic Dysfunction?
- Source :
- Biol Psychiatry
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Mild traumatic brain injury (mTBI), often referred to as concussion, is a major cause of morbidity and mortality worldwide. Sleep disturbances are common after mTBI. Moreover, subjects who develop subjective sleep complaints after mTBI also report more severe somatic, mental health, and cognitive impairment and take longer to recover from mTBI sequelae. Despite many previous studies addressing the role of sleep in post-mTBI morbidity, the mechanisms linking sleep to recovery after mTBI remain poorly understood. The glymphatic system is a brain-wide network that supports fluid movement through the cerebral parenchyma and the clearance of interstitial solutes and wastes from the brain. Notably, the glymphatic system is active primarily during sleep. Clearance of cellular byproducts related to somatic, mental health, and neurodegenerative processes (e.g., amyloid-β and tau, among others) depends in part on intact glymphatic function, which becomes impaired after mTBI. In this viewpoint, we review the current knowledge regarding the association between sleep disturbances and post-mTBI symptoms. We also discuss the role of glymphatic dysfunction as a potential link between mTBI, sleep disruption, and post-traumatic morbidity. We outline a model where glymphatic dysfunction and sleep disruption caused by mTBI may have an additive effect on waste clearance, leading to cerebral dysfunction and impaired recovery. Finally, we review the novel techniques being developed to examine glymphatic function in humans and explore potential interventions to alter glymphatic exchange that may offer a novel therapeutic approach to those suffering from poor sleep and prolonged symptoms after mTBI.
- Subjects :
- Sleep Wake Disorders
medicine.medical_specialty
business.industry
Traumatic brain injury
medicine.disease
Sleep in non-human animals
Article
Poor sleep
Therapeutic approach
Physical medicine and rehabilitation
Subjective sleep
Brain Injuries, Traumatic
Concussion
Humans
Medicine
Glymphatic system
Sleep
business
Cognitive impairment
Glymphatic System
Brain Concussion
Biological Psychiatry
Subjects
Details
- ISSN :
- 00063223
- Volume :
- 91
- Database :
- OpenAIRE
- Journal :
- Biological Psychiatry
- Accession number :
- edsair.doi.dedup.....8a8da06dcf77e3caa87dbe00b7d6aabe
- Full Text :
- https://doi.org/10.1016/j.biopsych.2021.06.025