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Erdheim-Chester disease: report of a case with PCR-based analysis of the expression of osteopontin and survivin in Xanthogranulomas following glucocorticoid treatment
- Source :
- Endocrine journal. 55(1)
- Publication Year :
- 2008
-
Abstract
- Erdheim-Chester disease (ECD) is a form of non-Langerhans histiocytosis. In this report, we show a case of ECD presenting diabetes insipidus and multiple xanthogranulomas received glucocorticoid treatment over a year. During this period, xanthogranulomas improved in response to the glucocorticoid therapy. Furthermore, the expression of osteopontin in xanthogranulomatous tissues significantly decreased following the treatment. Our data show the expression of osteopontin in xanthogranulomatous tissues of ECD. Furthermore, the osteopontin mRNA decreased following glucocorticoid therapy with xanthogranuloma regression, suggesting that the expression level of osteopontin could be a marker of the disease activity of ECD.
- Subjects :
- Adult
medicine.medical_specialty
Pathology
Erdheim-Chester Disease
genetic structures
Endocrinology, Diabetes and Metabolism
Prednisolone
Survivin
Gene Expression
Disease
Polymerase Chain Reaction
Inhibitor of Apoptosis Proteins
Endocrinology
stomatognathic system
Internal medicine
medicine
Xanthomatosis
Humans
Osteopontin
Glucocorticoids
Messenger RNA
Granuloma
biology
business.industry
medicine.disease
eye diseases
Neoplasm Proteins
Histiocytosis
Diabetes insipidus
Erdheim–Chester disease
biology.protein
Female
business
Microtubule-Associated Proteins
Glucocorticoid
medicine.drug
Follow-Up Studies
Subjects
Details
- ISSN :
- 13484540
- Volume :
- 55
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Endocrine journal
- Accession number :
- edsair.doi.dedup.....8ab668b9c9b26bbadae201a7e77f0a4a