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Serum anti-lysozyme is associated with disease activity of Behçet's disease
- Source :
- International Journal of Rheumatic Diseases. 20:261-268
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Objectives We investigated the association between autoantibodies against non-myeloperoxidase (MPO) neutrophil granule antigens and activity of Behcet's disease (BD). Methods We consecutively enrolled 51 BD patients. We assessed clinical data and BD activity using patients' index scores from the Behcet's Disease Current Activity Form and we performed tests for antibodies against proteinase 3 (PR3), MPO, bactericidal permeability increasing protein (BPI), cathepsin G, elastase, lactoferrin and lysozyme. Results The median patient index score was 2.0, and 56.9% of patients had active BD. In multivariate analysis of variables with significant correlations, only anti-lysozyme showed a significant correlation with BD activity (P = 0.002). In multivariate logistic regression analyses of variables, when patients were classified into groups according to the optimal cutoff levels of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and anti-lysozyme (ESR > 42.5 mm/h, CRP > 1.35 mg/L and anti-lysozyme > 2.95 IU/mL), the variable with independent predictive value was anti-lysozyme (odds ratio 8.384, P = 0.015). Conclusion Anti-lysozyme was significantly correlated with disease activity score and it was the only independent value to predict active disease in patients with BD. Furthermore, patients having anti-lysozyme levels ≥ 2.95 IU/mL had a significantly higher risk of having active BD than those who did not.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Behcet's disease
Severity of Illness Index
Gastroenterology
Young Adult
03 medical and health sciences
0302 clinical medicine
Rheumatology
Predictive Value of Tests
Proteinase 3
Internal medicine
Odds Ratio
Humans
Medicine
Aged
Autoantibodies
030203 arthritis & rheumatology
Chi-Square Distribution
biology
medicine.diagnostic_test
business.industry
Lactoferrin
Behcet Syndrome
Elastase
Odds ratio
Middle Aged
Prognosis
medicine.disease
Bactericidal/permeability-increasing protein
Up-Regulation
Logistic Models
030104 developmental biology
Predictive value of tests
Erythrocyte sedimentation rate
Multivariate Analysis
Immunology
Linear Models
biology.protein
Female
Muramidase
business
Biomarkers
Subjects
Details
- ISSN :
- 17561841
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- International Journal of Rheumatic Diseases
- Accession number :
- edsair.doi.dedup.....8add1efe3629780cbb47e1375727f62e