Back to Search
Start Over
Exercise as a countermeasure for latent viral reactivation during long duration space flight
- Source :
- FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(2)
- Publication Year :
- 2019
-
Abstract
- Latent viral reactivation is a commonly reported manifestation of immune system dysregulation during spaceflight. As physical fitness and exercise training have been shown to benefit multiple arms of the immune system, we hypothesized that higher levels of preflight physical fitness and/or maintaining fitness during a mission would protect astronauts from latent viral reactivation. Standardized tests of maximal strength, muscular endurance, flexibility, and cardiorespiratory fitness (CRF) were performed in 22 international space station (ISS) crewmembers before and after a ~6-month mission. Reactivation of cytomegalovirus (CMV), Epstein-Barr virus (EBV), and varicella zoster virus (VZV) was determined in crewmembers and ground-based controls before, during, and after spaceflight. Crewmembers with higher CRF before spaceflight had a 29% reduced risk of latent viral reactivation compared to crew with lower CRF. Higher preflight upper body muscular endurance was associated with a 39% reduced risk of viral reactivation, a longer time to viral reactivation, and lower peak viral DNA concentrations, particularly for EBV and VZV. Latent viral reactivation rates were highest in crew with lower preflight CRF and higher levels of CRF deconditioning on return to Earth. We conclude that physical fitness may protect astronauts from latent viral reactivation during long duration spaceflight missions.
- Subjects :
- 0301 basic medicine
Adult
Male
Time Factors
viruses
Physical fitness
Crew
medicine.disease_cause
Spaceflight
Biochemistry
Virus
law.invention
03 medical and health sciences
0302 clinical medicine
Deconditioning
law
Genetics
medicine
Humans
Molecular Biology
Exercise
Herpesviridae
business.industry
Varicella zoster virus
Cardiorespiratory fitness
Herpesviridae Infections
Immune dysregulation
Middle Aged
Space Flight
Virus Latency
030104 developmental biology
Immunology
DNA, Viral
Female
Virus Activation
business
030217 neurology & neurosurgery
Biotechnology
Subjects
Details
- ISSN :
- 15306860
- Volume :
- 34
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES
- Accession number :
- edsair.doi.dedup.....8af4499a46e55ac9522ff38107fde365