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Undercarboxylated osteocalcin relates to cardiovascular risk markers in offspring of families with metabolic syndrome
- Source :
- Atherosclerosis. 233:272-277
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- The undercarboxylated form of osteocalcin (ucOC) is an emerging marker of cardiovascular disease. It is unknown if ucOC in related to common cardiovascular risk markers in children. In offspring of families with and without metabolic syndrome (MetS+ and MetS- families), we assessed whether ucOC was related to a continuous metabolic syndrome score (MetS score) and to carotid intima-media thickness (cIMT).ucOC and total OC, MetS score and cIMT were assessed in 203 asymptomatic prepubertal children (age 7.6 ± 0.1 yr; 49% girls), of whom 99 were from MetS+ families.In children from MetS+ families, percent ucOC was higher than in children from MetS- families (p0.01). In offspring from MetS+ families, higher ucOC and especially higher percent ucOC was independently associated with both the MetS score and cIMT (both p ≤ 0.01).The undercarboxylated form of OC is related to common cardiovascular risk markers in children at risk for cardiovascular disease.
- Subjects :
- Male
medicine.medical_specialty
Offspring
Osteocalcin
Disease
Carotid Intima-Media Thickness
Asymptomatic
Risk Factors
Internal medicine
medicine
Humans
Undercarboxylated osteocalcin
Child
Metabolic Syndrome
biology
business.industry
medicine.disease
Endocrinology
Intima-media thickness
Cardiovascular Diseases
Child, Preschool
biology.protein
Female
Metabolic syndrome
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 00219150
- Volume :
- 233
- Database :
- OpenAIRE
- Journal :
- Atherosclerosis
- Accession number :
- edsair.doi.dedup.....8b269c410d9eab42cadbf1cae3f97aa9