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Genotypic HIV-1 tropism determination might help to identify people with exhausted treatment options and advanced disease
- Publication Year :
- 2021
-
Abstract
- ObjectivesTo evaluate HIV-1 tropism in 1382 combined antiretroviral therapy (cART)-experienced patients failing therapy to characterize those with exhausted therapeutic options.MethodsHIV-1 genotypic tropism was inferred through Geno2Pheno by estimating the false-positive-rate (FPR) values. Cumulative resistance and drug activity were evaluated by Stanford algorithm.ResultsOverall, median (IQR) CD4 count (cells/mm3) nadir and at last genotypic resistance test (GRT) available were 98 (33–211) and 312 (155–517), respectively. Considering HIV-1 tropism, 30.5% had X4/dual-mixed strains (FPR ≤5%: 22.2%; FPR 5%–10%: 8.3%). By stratifying according to tropism, by decreasing FPR, a significant decrease of CD4 nadir and at last GRT was observed. The proportion of individuals with CD4 count ConclusionsOur findings showed that a small proportion of cART failing individuals have limited therapeutic options. However, tropism determination might help to identify people who have accumulated a high level of resistance and have a greater risk of advanced disease.
- Subjects :
- Microbiology (medical)
Cart
medicine.medical_specialty
Genotype
Human immunodeficiency virus (HIV)
HIV Infections
medicine.disease_cause
Tropism
Settore MED/07
Internal medicine
medicine
Advanced disease
Humans
Pharmacology (medical)
Pharmacology
business.industry
virus diseases
Treatment options
Viral Load
Antiretroviral therapy
CD4 Lymphocyte Count
Viral Tropism
Infectious Diseases
Genotypic resistance
HIV-1
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....8b34634d523394e7a24c309597e9dcda