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Analyzing the mechano-bactericidal effect of nano-patterned surfaces on different bacteria species
- Publication Year :
- 2021
-
Abstract
- Mechano-bactericidal effects exhibited by specific nano-patterns have brought in the prospect of developing sustainable antibacterial materials. Contrary to the standard practices of administrating anti-bacterial agents or chemical surface functionalization, nano-patterns manage to inactivate a wide variety of bacteria species with no risk of toxicity, antibiotic resistance or replenishment. Herein, the experimental data on the bactericidal effect of nano-patterns were collected to develop in-silico models for identifying the impact of individual geometrical features. An artificial neural network was developed considering the three prevalent species of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The roles of individual geometrical features were analyzed and comprehensive parametric and sensitivity analyses were performed to determine the most favorable range for each parameter against different species. Geometrical features that would demonstrate bactericidal effects simultaneously against all the three studied species were identified. The efficient geometrical parameters, obtained from the artificial neural network analysis, were then used to develop a series of finite element models to simulate the physical interaction between the bacteria and the nano-patterns that result in inactivation. The obtained results can pave the way for unlocking the role of geometrical features towards optimized development of artificial materials with sustainable intrinsic antibacterial characteristics.
- Subjects :
- Artificial neural network
Materials science
Bactericidal surfaces
02 engineering and technology
03 medical and health sciences
Nano
Materials Chemistry
Finite element modeling
Sensitivity analyses
030304 developmental biology
Nano-morphology
0303 health sciences
Artificial materials
biology
Surfaces and Interfaces
General Chemistry
Physical interaction
021001 nanoscience & nanotechnology
Condensed Matter Physics
biology.organism_classification
Bactericidal effect
Surfaces, Coatings and Films
Surface modification
Antibacterial surfaces
0210 nano-technology
Biological system
Bacteria
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....8b43b2b377cf0cca0d4d2d1a2bd323fa