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Exploring Epigenetic Age in Response to Intensive Relaxing Training: A Pilot Study to Slow Down Biological Age
- Source :
- International Journal of Environmental Research and Public Health, Vol 16, Iss 17, p 3074 (2019), International Journal of Environmental Research and Public Health, Volume 16, Issue 17
- Publication Year :
- 2019
-
Abstract
- DNA methylation (DNAm) is an emerging estimator of biological aging, i.e., the often-defined &ldquo<br />epigenetic clock&rdquo<br />with a unique accuracy for chronological age estimation (DNAmAge). In this pilot longitudinal study, we examine the hypothesis that intensive relaxing training of 60 days in patients after myocardial infarction and in healthy subjects may influence leucocyte DNAmAge by turning back the epigenetic clock. Moreover, we compare DNAmAge with another mechanism of biological age, leucocyte telomere length (LTL) and telomerase. DNAmAge is reduced after training in healthy subjects (p = 0.053), but not in patients. LTL is preserved after intervention in healthy subjects, while it continues to decrease in patients (p = 0.051). The conventional negative correlation between LTL and chronological age becomes positive after training in both patients (p &lt<br />0.01) and healthy subjects (p &lt<br />0.05). In our subjects, DNAmAge is not associated with LTL. Our findings would suggest that intensive relaxing practices influence different aging molecular mechanisms, i.e., DNAmAge and LTL, with a rejuvenating effect. Our study reveals that DNAmAge may represent an accurate tool to measure the effectiveness of lifestyle-based interventions in the prevention of age-related diseases.
- Subjects :
- Male
Oncology
Aging
medicine.medical_specialty
Longitudinal study
Health, Toxicology and Mutagenesis
Biological age
Psychological intervention
lcsh:Medicine
Pilot Projects
Relaxation Therapy
telomerase
relaxing training
Article
Epigenesis, Genetic
DNA methylation age
epigenetic age
myocardial infarction patient
telomere length
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Longitudinal Studies
Epigenetics
Myocardial infarction
Aged
030304 developmental biology
0303 health sciences
Mechanism (biology)
business.industry
lcsh:R
Public Health, Environmental and Occupational Health
dNaM
DNA Methylation
medicine.disease
Treatment Outcome
DNA methylation
Female
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- International Journal of Environmental Research and Public Health, Vol 16, Iss 17, p 3074 (2019), International Journal of Environmental Research and Public Health, Volume 16, Issue 17
- Accession number :
- edsair.doi.dedup.....8b512bd4546fd2825ad5b04a0508a581