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Galanin Receptor 1 Plays an Antinociceptive Effect via Inhibiting PKA Activation in the Nucleus Accumbens of Rats With Neuropathic Pain

Authors :
Y. Zhang
Ya-Nan Liu
Y. Gao
W. Dong
Yan Dong
Meng-Nan Li
C.-Y. Li
Shi-Lian Xu
Source :
Physiological Research. :511-518
Publication Year :
2019
Publisher :
Institute of Physiology of the Czech Academy of Sciences, 2019.

Abstract

Galanin and galanin receptors (GalRs) have been reported to be involved in the transmission and modulation of nociceptive information in the central nervous system (CNS). However, the underlying mechanism of the antinociception of GalRs in neuropathic pain remains unclear. This study investigated the antinociception induced by galanin receptor 1 (GalR1) via protein kinase A (PKA) signaling pathway in the nucleus accumbens (NAc) of rats with neuropathic pain. A mononeuropathy model was replicated by ligation of the left sciatic nerve, following which the expression of phospho-PKA (p-PKA) in the NAc were markedly up-regulated at 14th and 28th day after ligation of sciatic nerve, and p-PKA expression was down-regulated by intra-NAc injection of GalR1 agonist M617, but the GalR1 antagonist M35 did not have an effect. We also found that M35 in the NAc blocked the M617-induced increase in the hind paw withdrawal latencies (HWLs) of rats with mononeuropathy, but M35 alone had no effect on HWLs, and PKA inhibitor H-89 attenuated the M617-induced an increase in the HWLs. These results suggested that GalR1 induced an antinociception via inhibiting PKA activation, implying that GalR agonists may be potential and potent therapeutic options to treat chronic neuropathic pain.

Details

ISSN :
18029973 and 08628408
Database :
OpenAIRE
Journal :
Physiological Research
Accession number :
edsair.doi.dedup.....8b5ce82c5c4889ac69a739f7cd0b7053
Full Text :
https://doi.org/10.33549/physiolres.933941