Back to Search Start Over

Next-Generation Influenza Vaccines

Authors :
Masaru Kanekiyo
Barney S. Graham
Source :
Cold Spring Harbor perspectives in medicine. 11(8)
Publication Year :
2023

Abstract

Most currently used conventional influenza vaccines are based on 1940s technology. Advances in vaccine immunogen design and delivery emerging over the last decade promise new options for improving influenza vaccines. In addition, new technologies for immune profiling provide better-defined immune correlates of protection and precise surrogate biomarkers for vaccine evaluations. Major technological advances include single-cell analysis, high-throughput antibody discovery, next-generation sequencing of antibody gene transcripts, antibody ontogeny, structure-guided immunogen design, nanoparticle display, delivery and formulation options, and better adjuvants. In this review, we provide our prospective outlook for improved influenza vaccines in the foreseeable future.

Details

ISSN :
21571422
Volume :
11
Issue :
8
Database :
OpenAIRE
Journal :
Cold Spring Harbor perspectives in medicine
Accession number :
edsair.doi.dedup.....8b5f9507bccfa2bcef92c53bd6959c77