A direct effect of dibutyryl cycluc AMP on the duration of narcosis induced by sedative, hypnotic, tranquiliser and anaesthetic drugs in the rat

The ability of exogenously administered N6, O2′-dibutyryl analogue of cyclic AMP to shorten, in a dose-related manner, the duration of narcosis of eight structurally different agents (chloral hydrate, paraldehyde, diazepam, amobarbital, halothane, ketamine, ethanol and methanol) has been demonstrated in the rat. No other nucleotide, neurotransmitter, biogenic amine or hormone tested, shortened, in a dose-related manner the sleeping time induced by the anaesthetic agents.