Back to Search
Start Over
Risks of Bleeding and Stroke Based on CHA2DS2‐VASc Scores in Japanese Patients With Atrial Fibrillation: A Large‐Scale Observational Study Using Real‐World Data
- Source :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
- Publication Year :
- 2020
- Publisher :
- John Wiley and Sons Inc., 2020.
-
Abstract
- Background This large‐scale observational study on negative events in a real‐world setting investigated Japanese patients with atrial fibrillation who were not on anticoagulants. This study aims to evaluate the incidence of ischemic stroke and bleeding events (intracranial hemorrhage, gastrointestinal bleeding, others) based on CHA 2 DS 2‐ VAS c scores in Japanese patients with atrial fibrillation who were not anticoagulated. Methods and Results We used health checkups and insurance claim data from a Japanese insurance organization. Altogether, 9733 atrial fibrillation patients were not prescribed anticoagulation during their follow‐up periods. Patients’ risk levels were defined by their CHA 2 DS 2‐ VAS c scores (range 0–≥3): Men with scores of 0, 1, or ≥2 and women with scores of 1, 2, or ≥3 were considered at low, intermediate, or high risk, respectively. Cox proportional hazards model was used to assess the association between the CHA 2 DS 2‐ VAS c‐determined risk and the incidence of ischemic stroke and intracranial, gastrointestinal, and other bleeding. The mean 2.5‐year follow‐up revealed 143 ischemic strokes and 332 bleeding events. Annual event rates were 0.58% for ischemic stroke and 1.17% for total bleeding events. Annual incidence of ischemic stroke increased with elevated predicted risks based on CHA 2 DS 2‐ VAS c scores: 0.18% for low‐risk, 0.44% intermediate‐risk, and 1.29% high‐risk groups ( P P Conclusions Risks of ischemic stroke and bleeding events were high, particularly among those with high CHA 2 DS 2‐ VAS c scores.
- Subjects :
- Adult
Male
medicine.medical_specialty
Gastrointestinal bleeding
030204 cardiovascular system & hematology
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Japan
Risk Factors
Internal medicine
Atrial Fibrillation
medicine
ischemic stroke
Humans
030212 general & internal medicine
Stroke
Original Research
Intracranial Hemorrhage
Aged
business.industry
Proportional hazards model
Incidence (epidemiology)
Incidence
Atrial fibrillation
Middle Aged
medicine.disease
bleeding
CHA2DS2–VASc score
Ischemic stroke
Observational study
Female
CHA2DS2‐VASc score
Cardiology and Cardiovascular Medicine
business
Gastrointestinal Hemorrhage
Intracranial Hemorrhages
Subjects
Details
- Language :
- English
- ISSN :
- 20479980
- Volume :
- 9
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
- Accession number :
- edsair.doi.dedup.....8b954fa6340d7e0b39f900b9beb7b6c8