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Genomic aberrations associated with outcome in anaplastic oligodendroglial tumors treated within the EORTC phase III trial 26951
- Source :
- Idbaih, A, Dalmasso, C, Kouwenhoven, M, Jeuken, J, Carpentier, C, Gorlia, T, Kros, J M, French, P, Teepen, J, Broët, P, Delattre, O, Mokhtari, K, Sanson, M, Delattre, J-Y, van den Bent, M & Hoang-Xuan, K 2011, ' Genomic aberrations associated with outcome in anaplastic oligodendroglial tumors treated within the EORTC phase III trial 26951 ', Journal of Neuro-Oncology, vol. 103, no. 2, pp. 221-30 . https://doi.org/10.1007/s11060-010-0380-9, Journal of Neuro-Oncology, Journal of Neuro-Oncology, 103, 221-30, Journal of Neuro-Oncology, 103, 2, pp. 221-30, Journal of Neuro-Oncology, 103(2), 221-30. Kluwer Academic Publishers, Journal of Neuro-Oncology, 103(2), 221-230. Kluwer Academic
- Publication Year :
- 2011
-
Abstract
- Despite similar morphological aspects, anaplastic oligodendroglial tumors (AOTs) form a heterogeneous clinical subgroup of gliomas. The chromosome arms 1p/19q codeletion has been shown to be a relevant biomarker in AOTs and to be perfectly exclusive from EGFR amplification in gliomas. To identify new genomic regions associated with prognosis, 60 AOTs from the EORTC trial 26951 were analyzed retrospectively using BAC-array-based comparative genomic hybridization. The data were processed using a binary tree method. Thirty-three BACs with prognostic value were identified distinguishing four genomic subgroups of AOTs with different prognosis (p
- Subjects :
- Oncology
Male
Cancer Research
Pathology
Chromosomes, Artificial, Bacterial
medicine.medical_treatment
BAC-array based comparative genomic hybridization (aCGH)
Kaplan-Meier Estimate
Anaplastic Oligodendroglioma
Lomustine
Antineoplastic Combined Chemotherapy Protocols
Multicenter Studies as Topic
Oligodendroglial Tumor
In Situ Hybridization, Fluorescence
Comparative Genomic Hybridization
Brain Neoplasms
Laboratory Investigation - Human/Animal Tissue
Middle Aged
Prognosis
Phenotype
Combined Modality Therapy
Treatment Outcome
Neurology
Vincristine
Biomarker (medicine)
Adult
medicine.medical_specialty
Oligodendroglioma
Clinical Neurology
Biology
Chromosome
Young Adult
Translational research [ONCOL 3]
Internal medicine
medicine
Biomarkers, Tumor
Humans
Aged
Proportional Hazards Models
Retrospective Studies
Chromosome Aberrations
Radiotherapy
Proportional hazards model
medicine.disease
Radiation therapy
Fluorescent in situ hybridization (FISH)
Procarbazine
Neurology (clinical)
Comparative genomic hybridization
Subjects
Details
- Language :
- English
- ISSN :
- 0167594X
- Volume :
- 103
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of Neuro-Oncology
- Accession number :
- edsair.doi.dedup.....8b95a9a09a9704e753d035d722cc2c59