Back to Search
Start Over
Frailty index is associated with increased risk of elevated BNP in an elderly population: the Rugao Longevity and Ageing Study
- Source :
- Aging clinical and experimental research. 32(2)
- Publication Year :
- 2019
-
Abstract
- To explore whether frailty, defined by frailty index (FI), is associated with the risk of elevated B-type natriuretic peptide (BNP), a surrogate endpoint of cardiovascular events. Data of 1382 community-dwelling elders who had no documented cardiovascular diseases aged 70–84 years from the ageing arm of the Rugao Longevity and Ageing Study was used. Traditional risk factor index (TI) was constructed using eight established cardiovascular-related risk factors. FI was constructed using 36 health deficits. Elevated BNP was defined as BNP ≥ 100pg/mL. Cardiovascular events include incident major cardiovascular events and cardiovascular death. During a 3-year follow-up period, 97 participants had cardiovascular events. TI was not associated with the risk of elevated BNP, but was associated with cardiovascular events (HR = 1.16, 95% CI 1.01–1.34). Frailty index was not only associated with cardiovascular events (HR = 1.32, 95% CI 1.06–1.64), but also associated with elevated BNP with an OR of 1.22 (95% CI 1.02–1.47) for each 0.1 increment. Further, both frailty (OR = 1.93, 95% CI 1.67–3.17) and pre-frailty (OR = 1.54, 95% CI 1.06–2.25) were associated with increased risk of elevated BNP. FI is associated with increased risks of both cardiovascular events and surrogated endpoint of cardiovascular disease—elevated BNP. Frailty may be a non-traditional risk factor of cardiovascular diseases and frailty index may be a measurement for early identifying high risk elderly individuals of cardiovascular abnormities.
- Subjects :
- Male
Aging
medicine.medical_specialty
medicine.drug_class
media_common.quotation_subject
Longevity
Frailty Index
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Elderly population
Natriuretic Peptide, Brain
medicine
Natriuretic peptide
Humans
030212 general & internal medicine
Risk factor
media_common
Aged
Aged, 80 and over
Frailty
Surrogate endpoint
business.industry
Increased risk
Ageing
Cardiovascular Diseases
Female
Independent Living
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- ISSN :
- 17208319
- Volume :
- 32
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Aging clinical and experimental research
- Accession number :
- edsair.doi.dedup.....8baccfc8705b73cc99bd95790d7f94d8