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Current perspective on the regulation of FOXO4 and its role in disease progression
- Source :
- Cellular and Molecular Life Sciences. 77:651-663
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Forkhead box O4 (FOXO4) is a member of the FOXO family that regulates a number of genes involved in metabolism, cell cycle, apoptosis, and cellular homeostasis via transcriptional activity. It also mediates cell responses to oxidative stress and treatment with antitumor agents. The expression of FOXO4 is repressed by microRNAs in multiple cancer cells, while FOXO4 function is regulated by post-translational modifications and interaction with other proteins. The deregulation of FOXO4 is closely linked to the progression of several types of cancer, senescence, and other diseases. In this review, we present recent findings on the regulation of FOXO4 in physiological and pathological conditions and provide an overview of the complex role of FOXO4 in disease development and response to therapy.
- Subjects :
- Transcriptional Activation
Senescence
Cellular homeostasis
Apoptosis
Cell Cycle Proteins
Biology
Cellular and Molecular Neuroscience
Neoplasms
microRNA
medicine
Animals
Humans
Protein Interaction Maps
Molecular Biology
Cell Proliferation
Pharmacology
Cell growth
Cancer
FOXO Family
Forkhead Transcription Factors
Cell Biology
Cell cycle
medicine.disease
Cell biology
Gene Expression Regulation, Neoplastic
Oxidative Stress
FOXO4
Disease Progression
Molecular Medicine
Protein Processing, Post-Translational
Subjects
Details
- ISSN :
- 14209071 and 1420682X
- Volume :
- 77
- Database :
- OpenAIRE
- Journal :
- Cellular and Molecular Life Sciences
- Accession number :
- edsair.doi.dedup.....8bc10d82b4da9b8d39ea65f6ff695650